Where do non-competitive inhibitors bind?

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Multiple Choice

Where do non-competitive inhibitors bind?

Non-competitive inhibitors bind to an allosteric site on the enzyme, a region separate from the active site. This binding changes the enzyme’s shape and lowers its catalytic efficiency, so the reaction rate drops even if the substrate is present. Because this interference isn’t about substrate binding, Km is often unchanged, while Vmax decreases. They don’t interact with the substrate or product, and can affect the enzyme whether or not the substrate is bound.

Non-competitive inhibitors bind to an allosteric site on the enzyme, a region separate from the active site. This binding changes the enzyme’s shape and lowers its catalytic efficiency, so the reaction rate drops even if the substrate is present. Because this interference isn’t about substrate binding, Km is often unchanged, while Vmax decreases. They don’t interact with the substrate or product, and can affect the enzyme whether or not the substrate is bound.

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