What can pass through a gap junction?

Prepare for the Foundations of Biology Exam 1. Dive into key biological concepts with multiple choice questions, hints, and explanations. Ace the exam with our efficient study methods!

Multiple Choice

What can pass through a gap junction?

Explanation:
Gap junctions create direct cytoplasmic connections between neighboring cells through channels formed by connexin proteins. These channels form a small, hydrophilic pore that permits diffusion of ions and small metabolites, such as Ca2+, cyclic AMP, IP3, and other signaling molecules, allowing rapid electrical and metabolic coupling between cells. Because the pore is limited in size and is aqueous, large macromolecules cannot pass: large proteins, lipids, and DNA are too big or not compatible with the channel environment.

Gap junctions create direct cytoplasmic connections between neighboring cells through channels formed by connexin proteins. These channels form a small, hydrophilic pore that permits diffusion of ions and small metabolites, such as Ca2+, cyclic AMP, IP3, and other signaling molecules, allowing rapid electrical and metabolic coupling between cells. Because the pore is limited in size and is aqueous, large macromolecules cannot pass: large proteins, lipids, and DNA are too big or not compatible with the channel environment.

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