From which molecule are IP3 and DAG derived?

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Multiple Choice

From which molecule are IP3 and DAG derived?

IP3 and DAG come from a membrane phospholipid called PIP2 (phosphatidylinositol 4,5-bisphosphate). When a receptor activates phospholipase C, this enzyme cleaves PIP2 into two second messengers: IP3, which diffuses into the cytosol to trigger Ca2+ release, and DAG, which stays in the membrane to help activate protein kinase C. ATP and GTP aren’t the substrates for this cleavage, and DAG isn’t the starting molecule—it's one product of the PIP2 cut.

IP3 and DAG come from a membrane phospholipid called PIP2 (phosphatidylinositol 4,5-bisphosphate). When a receptor activates phospholipase C, this enzyme cleaves PIP2 into two second messengers: IP3, which diffuses into the cytosol to trigger Ca2+ release, and DAG, which stays in the membrane to help activate protein kinase C. ATP and GTP aren’t the substrates for this cleavage, and DAG isn’t the starting molecule—it's one product of the PIP2 cut.

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