Prepare for the Foundations of Biology Exam 1. Dive into key biological concepts with multiple choice questions, hints, and explanations. Ace the exam with our efficient study methods!

Multiple Choice

Desmosomes are best described as structures that

Desmosomes provide strong cell–cell adhesion by linking intermediate filaments of neighboring cells. In epithelial cells, desmosomal cadherins (desmogleins and desmocollins) span the membranes and connect to plaque proteins such as desmoplakin and plakoglobin, which in turn bind to keratin intermediate filaments inside the cell. This arrangement distributes mechanical stress across cells, giving tissues like skin and heart their resilience. They are not channels for electrical coupling (that’s gap junctions) and they don’t primarily anchor actin filaments (that role belongs to adherens junctions). Hence, anchoring intermediate filaments to the cytoskeleton is the best description.

Desmosomes provide strong cell–cell adhesion by linking intermediate filaments of neighboring cells. In epithelial cells, desmosomal cadherins (desmogleins and desmocollins) span the membranes and connect to plaque proteins such as desmoplakin and plakoglobin, which in turn bind to keratin intermediate filaments inside the cell. This arrangement distributes mechanical stress across cells, giving tissues like skin and heart their resilience. They are not channels for electrical coupling (that’s gap junctions) and they don’t primarily anchor actin filaments (that role belongs to adherens junctions). Hence, anchoring intermediate filaments to the cytoskeleton is the best description.